Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models
نویسندگان
چکیده
منابع مشابه
Curcumin Attenuates Doxorubicin-Induced Cardiotoxicity by Inducing Autophagy via the Regulation of JNK Phosphorylation
Copyright: © 2014 Katamura M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Background and Objective: Doxorubicin (DOX) has been used in cancer therapy for several decades. However, cardiac c...
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Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive picture has yet to emerge. Autophagy, regarded generally as a protective mechanism that maintains ...
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Resveratrol is a plant-derived polyphenol that can attenuate the cardiotoxic effects of doxorubicin (DOX), a powerful antibiotic widely used in cancer chemotherapy. However, the underlying protective mechanisms of resveratrol remain elusive. Here, we show that resveratrol inhibited DOX-induced autophagy and cardiomyocyte death, and autophagy suppression is an important mechanism that mediates t...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2021
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2021.111375